TrueMed NMN Synergy+ – 60 Vegetarian Capsules, 700 mg Per Serving
About The Product
TrueMed NMN Synergy+ 60 Capsules is the full-month version of TrueMed’s advanced NAD+ longevity stack — delivering the same trusted 700 mg per serving formula (NMN 500 mg + Trans-Resveratrol 100 mg + Trans-Pterostilbene 100 mg) in a 60-capsule bottle providing a complete 30-day supply. For individuals who have committed to a daily NMN longevity protocol, the 60-capsule bottle provides the full monthly foundation for consistent, uninterrupted supplementation without frequent re-orders.
The formula’s architecture targets the two primary pillars of NAD+-mediated longevity biology: raising cellular NAD+ levels (through NMN’s direct salvage pathway conversion) and activating the sirtuin enzymes that depend on NAD+ as a substrate (through the dual polyphenol complex of Trans-Resveratrol and Trans-Pterostilbene). The inclusion of Trans-Pterostilbene alongside Resveratrol is what sets TrueMed NMN Synergy+ apart from most NMN products on the market. While Resveratrol is the historically studied sirtuin activator, its notoriously poor oral bioavailability (~1%) means that the vast majority of ingested Resveratrol never reaches systemic circulation. Trans-Pterostilbene — a naturally occurring methylated analog found in blueberries — achieves approximately 80% oral bioavailability due to its enhanced lipid solubility and resistance to first-pass metabolic degradation, providing more sustained sirtuin activation across each 24-hour dosing cycle. Together, the two polyphenols provide complementary rapid-onset (Resveratrol) and sustained (Pterostilbene) sirtuin pathway coverage — working synergistically with the NAD+ substrate elevation provided by 500 mg of NMN. Produced in a GMP-certified, UL-certified, FDA-registered USA facility by TrueMed Pharma Inc.
- NMN 500 mg: Directly converted to NAD+ intracellularly via the NMN salvage pathway — the most efficient oral route to raising cellular NAD+ levels demonstrated in human clinical trials.
- Trans-Resveratrol 100 mg: Biologically active resveratrol isomer — SIRT1 allosteric activator providing the rapid-onset sirtuin activation component of the dual polyphenol complex.
- Trans-Pterostilbene 100 mg: Methylated resveratrol analog with ~80% oral bioavailability, longer half-life, SIRT1/SIRT3 activation, and additional AMPK and PPAR-α pathway support for metabolic health and mitochondrial function.
- 30-Day Supply Format: 60 capsules providing 30 full 2-capsule servings — the optimal monthly supply format for a consistent, uninterrupted NAD+ longevity protocol.
NMN Intracellular Salvage Pathway NAD+ Biosynthesis
NMN enters cells via the Slc12a8 transporter and is directly phosphorylated to NAD+ through the salvage pathway — efficiently elevating intracellular NAD+ in a dose-dependent manner demonstrated across 30 days of consistent daily supplementation.
Trans-Resveratrol SIRT1 Allosteric Activation
Trans-Resveratrol binds SIRT1’s N-terminal domain and increases its NAD+-dependent deacetylase activity, activating cellular stress response, DNA repair signalling, and metabolic regulation through the longevity enzyme’s primary functional pathway.
Trans-Pterostilbene Sustained SIRT1/SIRT3 & AMPK Activation
Trans-Pterostilbene’s ~80% oral bioavailability and extended half-life provide sustained systemic sirtuin activation, AMPK phosphorylation for metabolic energy sensing, and PPAR-α activation for mitochondrial fatty acid oxidation — maintaining consistent longevity pathway engagement throughout the 30-day supply period.
Nrf2-Mediated Endogenous Antioxidant Upregulation
Both polyphenols activate Nrf2 transcription factor signalling, upregulating endogenous antioxidant enzymes (NQO1, HO-1, glutathione peroxidase) and supporting the cellular redox environment that underpins the DNA repair and mitochondrial health benefits of the sirtuin longevity pathway.
One Month. Every Day. The NAD+ Longevity Protocol That Compounds Over Time.
The science of healthy aging is clear on one point: consistency matters more than intensity. NAD+ levels respond to sustained daily NMN supplementation. Sirtuin activation accumulates with regular polyphenol intake. Mitochondrial health improves incrementally with continued support. TrueMed NMN Synergy+ 60 Capsules is the full 30-day supply format built for people who understand this — a complete month of the advanced dual-polyphenol NMN stack (500 mg NMN + 100 mg Trans-Resveratrol + 100 mg Trans-Pterostilbene) with no interruption, no re-ordering mid-month, no breaks in the protocol. Two capsules with breakfast, every day, for 30 days. That’s the longevity investment. Vegan, non-GMO, produced in a GMP-certified, UL-certified USA facility.
