TrueMed NMN Synergy+ is a three-ingredient NAD+ longevity support formula combining NMN (Nicotinamide Mononucleotide) with a dual sirtuin-activating polyphenol complex of Trans-Resveratrol and Trans-Pterostilbene. This combination targets the two primary pillars of the modern longevity supplement science: raising cellular NAD+ levels (through NMN supplementation) and activating the sirtuin enzymes that depend on NAD+ for their biological activity (through Trans-Resveratrol and Trans-Pterostilbene).

NAD+ is a coenzyme essential to cellular energy metabolism, DNA repair, and the regulation of hundreds of enzymes. NAD+ levels decline significantly with age — with estimates suggesting levels fall by 50% or more between young adulthood and middle age. This age-related NAD+ decline is increasingly linked to the hallmarks of biological aging: impaired mitochondrial function, reduced cellular energy production, diminished DNA repair capacity, and altered sirtuin activity. NMN is converted to NAD+ through the intracellular NMN-to-NAD+ salvage pathway, bypassing the more inefficient niacin conversion route. At 500 mg per serving, this is within the dose range demonstrating meaningful NAD+ elevation in published human clinical research. Trans-Pterostilbene’s inclusion alongside Resveratrol is the formula’s most important differentiating feature — it provides sirtuin activation through a more bioavailable polyphenol that achieves higher and more sustained blood levels than equivalent doses of resveratrol, extending and amplifying the sirtuin-activating effect of the combined polyphenol complex. Produced in a GMP-certified, UL-certified, FDA-registered USA facility by TrueMed Pharma Inc.

1. NMN 500 mg (Nicotinamide Mononucleotide): Direct NAD+ precursor converted via the intracellular salvage pathway — efficiently raises cellular and tissue NAD+ levels. Human clinical trials have demonstrated that oral NMN supplementation at 250–900 mg/day produces meaningful NAD+ elevation in blood and muscle tissue.
2. Trans-Resveratrol 100 mg: The trans isomer of resveratrol — the biologically active form that activates SIRT1 in a NAD+-dependent manner. Works synergistically with NMN: NMN raises NAD+ availability; Resveratrol activates the sirtuins that use NAD+ as a substrate.
3. Trans-Pterostilbene 100 mg: Methylated resveratrol analog from blueberries with ~80% oral bioavailability vs ~1% for resveratrol. Two methyl groups increase lipid solubility, reduce        metabolic degradation, and extend half-life — providing more sustained sirtuin activation at equivalent doses. Also activates AMPK and PPAR-α pathways relevant to metabolic health and fat oxidation.