TrueMed Super Berberine delivers a precision two-ingredient formula combining Dihydroberberine (250 mg) — the enhanced-bioavailability form of berberine — with a concentrated Ceylon Cinnamon Extract (200 mg of 20:1 extract, equivalent to 4,000 mg of whole cinnamon) in a single daily vegetarian capsule. The ‘Super’ designation refers specifically to the use of Dihydroberberine rather than standard berberine HCL — a meaningful distinction that makes this formula more effective and better tolerated than conventional berberine supplements.

Berberine is one of the most extensively researched natural compounds for blood sugar metabolism, with over 2,000 published studies supporting its role in AMPk activation, insulin sensitization, and glucose metabolism. Dihydroberberine (DHB) is a reduced form of berberine that studies show is absorbed approximately 5 times more efficiently than berberine HCL — achieving higher plasma berberine levels at lower doses with substantially reduced gastrointestinal side effects (bloating, cramping, diarrhea) that commonly limit regular berberine use. Ceylon Cinnamon (Cinnamomum verum) adds complementary glucose metabolism support through insulin receptor sensitization pathways, plus antioxidant and anti-inflammatory benefits — and critically, is the low-coumarin ‘true cinnamon’ safe for daily long-term supplementation, unlike cassia cinnamon which contains high levels of hepatotoxic coumarin. Produced in a GMP-certified, UL-certified, FDA-registered USA facility by TrueMed Pharma Inc.

1. Dihydroberberine (DHB) 250 mg: The reduced metabolite form of berberine — 5x more bioavailable than berberine HCL, faster intestinal absorption, and significantly gentler on the digestive system. 250 mg DHB delivers the plasma berberine equivalent of approximately 1,000–1,250 mg standard berberine HCL.
2. Ceylon Cinnamon Extract 200 mg (20:1 = 4,000 mg equivalent): Cinnamomum verum — the true, low-coumarin cinnamon from Sri Lanka. The 20:1 concentration ratio means 200 mg of this extract provides the active compound equivalent of 4,000 mg of whole Ceylon cinnamon powder, in a compact and stable form.
3. AMPk Activation + Insulin Sensitization Dual Mechanism: Berberine activates AMP-activated protein kinase (AMPk), improving cellular glucose uptake independent of insulin; Ceylon cinnamon enhances insulin receptor sensitivity, reducing insulin resistance. Together they address glucose metabolism from two complementary and synergistic pathways.
4. Coumarin-Safe Daily Use: Ceylon cinnamon contains very low levels of coumarin (≤0.004% versus cassia’s ~0.07–1%), making it safe for daily supplementation at high doses — unlike cassia cinnamon which exceeds safe coumarin limits at doses used in metabolic supplements.